Which option is NOT listed as an antidote/reversal agent in the overdose/poisoning protocol?

• A. Naloxone
• B. Epinephrine
• C. Hydroxocobalamin
• D. Diphenhydramine

Answer: (B)

In overdose/poisoning protocols, antidotes or reversal agents are substances that directly counteract a specific toxin’s effect. Naloxone reverses opioid toxicity by displacing opioids from receptor sites, restoring respiration. Hydroxocobalamin binds cyanide to form a safely excreted compound, countering cyanide poisoning. Diphenhydramine isn’t an antidote to a particular toxin; it’s an antihistamine that may be involved in general symptom management but does not reverse a specific poisoning mechanism. Epinephrine, while crucial in treating life-threatening allergic reactions and used as a vasopressor in certain toxin-induced shocks, is not an antidote that neutralizes a poison. Therefore, epinephrine is not listed as an antidote/reversal agent in the overdose/poisoning protocol.