Which option best reflects the anaphylaxis definition criteria?

• A. Exposure to allergen with hypotension OR respiratory compromise
• B. Skin rash only
• C. GI symptoms only
• D. Hives with localized swelling only

Answer: (A)

Anaphylaxis is a rapid, systemic allergic reaction after exposure to an allergen that involves more than one body system. The defining clue is that after exposure, there are signs of involvement of essential systems such as the cardiovascular or respiratory system, not just a single area. So, when you see exposure to an allergen plus either hypotension (low blood pressure) or respiratory compromise, that combination reflects the multi-system, life-threatening nature of anaphylaxis.

The other options show symptoms confined to a single system—skin rash alone, gastrointestinal symptoms alone, or hives with localized swelling—which do not meet the criteria for anaphylaxis because they don’t demonstrate the necessary systemic involvement.