What routes are allowed for Diphenhydramine in the no-anaphylaxis protocol?

• A. IM only
• B. IV only
• C. IM/IV/IO/PO
• D. PO only

Answer: (C)

Diphenhydramine in the no-anaphylaxis protocol is allowed to be given through multiple routes to ensure timely treatment in different patient situations. Using IM, IV, IO, or PO allows flexibility: IM for quick, easy administration when IV access isn’t yet available; IV for rapid effect when IV access is established; IO as a reliable alternative if IV access cannot be obtained; and PO for patients who can swallow and are not at risk of vomiting or airway compromise. This mix of routes ensures you can deliver the antihistamine promptly regardless of how the patient presents or what access you have. Limiting to a single route would delay or complicate treatment in some scenarios.