What is the maximum single dose of fentanyl for pediatric severe pain?

• A. 25 mcg
• B. 50 mcg
• C. 200 mcg
• D. 100 mcg

Answer: (D)

Dosing fentanyl for pediatric severe pain is weight-based, but there is a safety cap on a single administration. The standard approach is 1-2 mcg/kg, but you must not exceed 100 mcg in one dose. This cap helps prevent respiratory depression and other serious opioid effects in children with varying weights and respiratory reserves. In practice, a lighter child will receive well under 100 mcg, while a heavier child could approach the limit but should never exceed it. If pain persists after reassessment, subsequent dosing can be considered within protocol, with close monitoring for airway and breathing and readiness to intervene if needed.