In non-traumatic shock, what is the push-dose epinephrine concentration and dose?

• A. 1:10,000; 100 mcg per dose
• B. 1:100,000; 10 mcg per dose
• C. 1:1,000; 1 mg per dose
• D. 1:100,000; 1 mcg per dose

Answer: (B)

Push-dose epinephrine for non-traumatic shock is given as a small, rapidly titratable bolus to quickly raise blood pressure without committing to a continuous infusion. The standard approach uses a diluted 1:100,000 solution, delivering about 10 micrograms per dose. This concentration is achieved by diluting 1:10,000 epinephrine (which is 100 micrograms per milliliter) with saline to yield 10 micrograms per milliliter, so a 1 mL bolus provides 10 micrograms. Repeated doses every few minutes are guided by blood pressure and perfusion, allowing careful titration.